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From the early 1960s, when the average lifespan in the United States was about 70, lifelong habitual cigarette smokers were observed to die from lung cancer at ages between 55 and 65. This observation, which associated early death with cigarette smoke, identified cigarette smoke as a risk factor. ASSESSMENT OF RISK Risk assessment is a system of analysis that includes four tasks: • • • • identification of a substance (a toxicant) that may have adverse health effects, scenarios for exposure to the toxicant, characterization of health effects, and an estimate of the probability (risk) of occurrence of these health effects.

The response of an organism to a pollutant always depends in some way on the amount or dose of pollutant to the organism. The magnitude of the dose, in turn, depends on the exposure pathway. The same substance may have a different effect depending on whether it is inhaled, ingested, or absorbed through the skin, or whether the exposure is external. The exposure pathway determines the biochemistry of the pollutant in the organism. In general, the human body detoxifies an ingested pollutant more efficiently than an inhaled pollutant.

Socioeconomic considerations such as population increases, need for public services like schools, and increased or decreased job availability are also included under NEPA considerations. Very recently (O’Leary 1995), federal agencies have also mandated inclusion of environmental justice considerations in environmental impact assessments. Frequently, public acceptability is also a necessary input to an evaluation process. Although an alternative may protect public health and minimize environmental degradation, it may not be generally acceptable.

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